Neutrophil-generated HOCl leads to non-specific thiol oxidation in phagocytized bacteria

Phagocytic immune cells kill pathogens in the phagolysosomal compartment with a cocktail of antimicrobial agents. Chief among them are reactive species produced in the so-called oxidative burst. Here, we show that bacteria exposed to a neutrophil-like cell line experience a rapid and massive oxidati...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Degrossoli, Adriana, Müller, Alexandra, Xie, Kaibo, Schneider, Jannis F, Bader, Verian, Winklhofer, Konstanze F, Meyer, Andreas J, Leichert, Lars I
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2018
Gaiak:
Biochemistry and Chemical Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839695/
https://ncbi.nlm.nih.gov/pubmed/29506649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32288
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