An increase in surface hydrophobicity mediates chaperone activity in N-chlorinated RidA

Under physiological conditions, Escherichia coli RidA is an enamine/imine deaminase, which promotes the release of ammonia from reactive enamine/imine intermediates. However, when modified by hypochlorous acid (HOCl), it turns into a potent chaperone-like holdase that can effectively protect E. coli...

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Detalhes bibliográficos
Main Authors: Marharyta Varatnitskaya, Julia Fasel, Alexandra Müller, Natalie Lupilov, Yunlong Shi, Kristin Fuchs, Marco Krewing, Christoph Jung, Timo Jacob, Barbara Sitek, Julia E. Bandow, Kate S. Carroll, Eckhard Hofmann, Lars I. Leichert
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-07-01
Colecção:Redox Biology
Assuntos:
N-Chlorination
Oxidation
Oxidative stress
E. coli
Chaperone
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231722001045
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