Anti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression

AIMS: The human ether-a-go-go-related gene (hERG) encodes the rapidly activating delayed rectifier potassium channel (I(Kr)). Malfunction of hERG/I(Kr) is the primary cause of acquired long QT syndrome (LQTS), an electrical disorder of the heart that can cause arrhythmias and sudden death. Patients...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Szendrey, John, Lamothe, Shawn M, Vanner, Stephanie, Guo, Jun, Yang, Tonghua, Li, Wentao, Davis, Jordan, Joneja, Mala, Baranchuk, Adrian, Zhang, Shetuan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648346/
https://ncbi.nlm.nih.gov/pubmed/30544220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy310
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