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Structural Characterization of a Human-Type Corrinoid Adenosyltransferase Confirms That Coenzyme B(12) Is Synthesized through a Four-Coordinate Intermediate(†,)

ATP:cob(I)alamin adenosyltransferases (ACAs) catalyze the transfer of the 5′-deoxyadenosyl moiety from ATP to the upper axial ligand position of cobalamin in the synthesis of coenzyme B(12). For the ACA-catalyzed reaction to proceed, cob(II)alamin must be reduced to cob(I)alamin in the enzyme active...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Maurice, Martin St., Mera, Paola, Park, Kiyoung, Brunold, Thomas C., Escalante-Semerena, Jorge C., Rayment, Ivan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6647012/
https://ncbi.nlm.nih.gov/pubmed/18452306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800132d
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