Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients

Previous studies have shown lipopolysaccharide from Gram-negative bacteria is cleared from the circulation via LDL receptors on hepatocytes, which are downregulated by PCSK9. Whether clearance of Gram positive bacterial lipoteichoic acid (LTA) shows similar dependence on PCSK9, and whether this is c...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Leung, Alex K. K., Genga, Kelly Roveran, Topchiy, Elena, Cirstea, Mihai, Shimada, Tadanaga, Fjell, Chris, Russell, James A., Boyd, John H., Walley, Keith R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6646337/
https://ncbi.nlm.nih.gov/pubmed/31332258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46745-0
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