Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients

Previous studies have shown lipopolysaccharide from Gram-negative bacteria is cleared from the circulation via LDL receptors on hepatocytes, which are downregulated by PCSK9. Whether clearance of Gram positive bacterial lipoteichoic acid (LTA) shows similar dependence on PCSK9, and whether this is c...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Leung, Alex K. K., Genga, Kelly Roveran, Topchiy, Elena, Cirstea, Mihai, Shimada, Tadanaga, Fjell, Chris, Russell, James A., Boyd, John H., Walley, Keith R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6646337/
https://ncbi.nlm.nih.gov/pubmed/31332258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46745-0
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