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Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
Teixobactin represents a new class of antibiotics with novel structure and excellent activity against Gram-positive pathogens and Mycobacterium tuberculosis. Herein, we report a one-pot reaction to conveniently construct the key building block l-allo-Enduracidine in 30-gram scale in just one hour a...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6646333/ https://ncbi.nlm.nih.gov/pubmed/31332172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11211-y |
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