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Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics

Teixobactin represents a new class of antibiotics with novel structure and excellent activity against Gram-positive pathogens and Mycobacterium tuberculosis. Herein, we report a one-pot reaction to conveniently construct the key building block l-allo-Enduracidine in 30-gram scale in just one hour  a...

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Vydáno v:Nat Commun
Hlavní autoři: Zong, Yu, Fang, Fang, Meyer, Kirsten J., Wang, Liguo, Ni, Zhihao, Gao, Hongying, Lewis, Kim, Zhang, Jingren, Rao, Yu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6646333/
https://ncbi.nlm.nih.gov/pubmed/31332172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11211-y
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