Effects of 5-aminolevulinic acid and sodium ferrous citrate on fibroblasts from individuals with mitochondrial diseases

Mitochondrial respiratory chain complexes II, III, and IV and cytochrome c contain haem, which is generated by the insertion of Fe(2+) into protoporphyrin IX. 5-Aminolevulinic acid (ALA) combined with sodium ferrous citrate (SFC) was reported to enhance haem production, leading to respiratory comple...

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Published in:Sci Rep
Main Authors: Shimura, Masaru, Nozawa, Naoko, Ogawa-Tominaga, Minako, Fushimi, Takuya, Tajika, Makiko, Ichimoto, Keiko, Matsunaga, Ayako, Tsuruoka, Tomoko, Kishita, Yoshihito, Ishii, Takuya, Takahashi, Kiwamu, Tanaka, Tohru, Nakajima, Motowo, Okazaki, Yasushi, Ohtake, Akira, Murayama, Kei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6646320/
https://ncbi.nlm.nih.gov/pubmed/31332208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46772-x
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