5‐Aminolevulinic acid/sodium ferrous citrate enhanced the antitumor effects of programmed cell death‐ligand 1 blockade by regulation of exhausted T cell metabolism in a melanoma model

Mitochondria are key cytoplasmic organelles. Their activation is critical for the generation of T cell proliferation and cytotoxicity. Exhausted tumor‐infiltrating T cells show a decreased mitochondrial function and mass. 5‐Aminolevulinic acid (5‐ALA), a natural amino acid that is only produced in t...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Hu, Xin, Que, Weitao, Hirano, Hiroshi, Wang, Zhidan, Nozawa, Naoko, Ishii, Takuya, Ishizuka, Masahiro, Ito, Hidenori, Takahashi, Kiwamu, Nakajima, Motowo, Tanaka, Tohru, Zhu, Ping, Guo, Wen‐Zhi, Li, Xiao‐Kang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253271/
https://ncbi.nlm.nih.gov/pubmed/33934440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14930
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