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Conservation of Potentially Druggable Cavities in Intrinsically Disordered Proteins
[Image: see text] Intrinsically disordered proteins (IDPs) exist in highly dynamic conformational ensembles, which pose a major obstacle for drug development targeting IDPs because traditional rational drug design relies on unique three-dimensional structures. Here, we analyzed the conservation (esp...
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| Publicado no: | ACS Omega |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2018
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6643371/ https://ncbi.nlm.nih.gov/pubmed/31458221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b02092 |
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