Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells

Presenilins 1 and 2 (PS1 and 2) are the catalytic subunits of γ-secretase, a multiprotein protease that cleaves amyloid protein precursor and other type I transmembrane proteins. Previous studies with mouse models or cells have indicated differences in PS1 and PS2 functions. We have recently reporte...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6643044/
https://ncbi.nlm.nih.gov/pubmed/31167792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008041
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