Osteoarthritis patients with high haemoglobin A1c have increased Toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium

PURPOSE: While research has identified diabetes mellitus (DM) as a risk factor for knee osteoarthritis (KOA), the underlying mechanisms are not fully understood. Studies suggest that Toll-like receptor 4 (TLR4) expression is elevated in osteoarthritic lesions of OA patients and in target tissues of...

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Veröffentlicht in:Diabetes Metab Syndr Obes
Hauptverfasser: Murata, Kosuke, Uchida, Kentaro, Takano, Shotaro, Shoji, Shintaro, Iwase, Dai, Inoue, Gen, Aikawa, Jun, Yokozeki, Yuji, Sekiguchi, Hiroyuki, Takaso, Masashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove 2019
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642645/
https://ncbi.nlm.nih.gov/pubmed/31406471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S209677
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