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Flexizyme-enabled benchtop biosynthesis of thiopeptides.
Thiopeptides are natural antibiotics that are fashioned from short peptides by multiple layers of post-translational modification. Their biosynthesis, in particular the pyridine synthases that form the macrocyclic antibiotic core, has attracted intensive research but is complicated by the challenges...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6642631/ https://ncbi.nlm.nih.gov/pubmed/30602112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b11521 |
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