Flexizyme-enabled benchtop biosynthesis of thiopeptides.

Thiopeptides are natural antibiotics that are fashioned from short peptides by multiple layers of post-translational modification. Their biosynthesis, in particular the pyridine synthases that form the macrocyclic antibiotic core, has attracted intensive research but is complicated by the challenges...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Fleming, Steven R., Bartges, Tessa E., Vinogradov, Alexander A., Kirkpatrick, Christine L., Goto, Yuki, Suga, Hiroaki, Hicks, Leslie M., Bowers, Albert A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642631/
https://ncbi.nlm.nih.gov/pubmed/30602112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b11521
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