Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma

BACKGROUND: Abnormal construction of the extracellular matrix (ECM) is intimately linked with carcinogenesis and the development of solid tumours, especially hepatocellular carcinoma (HCC). As the major component of the ECM, collagen plays a pivotal role in carcinogenesis. P4HA2, the essential enzym...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Wang, Tianjiao, Fu, Xueli, Jin, Tianzhi, Zhang, Lu, Liu, Bowen, Wu, Yue, Xu, Feifei, Wang, Xue, Ye, Kai, Zhang, Weiying, Ye, Lihong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642319/
https://ncbi.nlm.nih.gov/pubmed/31278071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.06.048
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