Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma

BACKGROUND: Abnormal construction of the extracellular matrix (ECM) is intimately linked with carcinogenesis and the development of solid tumours, especially hepatocellular carcinoma (HCC). As the major component of the ECM, collagen plays a pivotal role in carcinogenesis. P4HA2, the essential enzym...

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Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Wang, Tianjiao, Fu, Xueli, Jin, Tianzhi, Zhang, Lu, Liu, Bowen, Wu, Yue, Xu, Feifei, Wang, Xue, Ye, Kai, Zhang, Weiying, Ye, Lihong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642319/
https://ncbi.nlm.nih.gov/pubmed/31278071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.06.048
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