β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer

The limited clinical response observed in high-grade serous ovarian cancer (HG-SOC) with high frequency of TP53 mutations (mutp53) might be related to mutp53-driven oncogenic pathway network. Here we show that β-arrestin1 (β-arr1), interacts with YAP, triggering its cytoplasmic-nuclear shuttling. Th...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Tocci, Piera, Cianfrocca, Roberta, Di Castro, Valeriana, Rosanò, Laura, Sacconi, Andrea, Donzelli, Sara, Bonfiglio, Silvia, Bucci, Gabriele, Vizza, Enrico, Ferrandina, Gabriella, Scambia, Giovanni, Tonon, Giovanni, Blandino, Giovanni, Bagnato, Anna
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642155/
https://ncbi.nlm.nih.gov/pubmed/31324767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11045-8
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