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Essential genes shape cancer genomes through linear limitation of homozygous deletions

The landscape of somatic acquired deletions in cancer cells is shaped by positive and negative selection. Recurrent deletions typically target tumor suppressor, leading to positive selection. Simultaneously, loss of a nearby essential gene can lead to negative selection, and introduce latent vulnera...

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Publicat a:Commun Biol
Autors principals: Pertesi, Maroulio, Ekdahl, Ludvig, Palm, Angelica, Johnsson, Ellinor, Järvstråt, Linnea, Wihlborg, Anna-Karin, Nilsson, Björn
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642121/
https://ncbi.nlm.nih.gov/pubmed/31341961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0517-0
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