Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing

Therapeutic antibodies are transforming the treatment of cancer and autoimmune diseases. Today, a key challenge is finding antibodies against new targets. Phenotypic discovery promises to achieve this by enabling discovery of antibodies with therapeutic potential without specifying the molecular tar...

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Publicado en:Nat Commun
Main Authors: Mattsson, Jenny, Ekdahl, Ludvig, Junghus, Fredrik, Ajore, Ram, Erlandsson, Eva, Niroula, Abhishek, Pertesi, Maroulio, Frendéus, Björn, Teige, Ingrid, Nilsson, Björn
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904777/
https://ncbi.nlm.nih.gov/pubmed/33627649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21518-4
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