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Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census

Genomics and genome screening are proving central to the study of cancer. However, a good appreciation of the protein structures coded by cancer genes is also invaluable, especially for the understanding of functions, for assessing ligandability of potential targets, and for designing new drugs. To...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Malhotra, Sony, Alsulami, Ali F., Heiyun, Yang, Ochoa, Bernardo Montano, Jubb, Harry, Forbes, Simon, Blundell, Tom L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6641202/
https://ncbi.nlm.nih.gov/pubmed/31323058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219935
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