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Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues

The synthesis of two stable phomopsolide natural products (D and E) and two analogues is presented. The cytotoxicities of these four compounds are surveyed and compared across a panel of NCI-cancer cell lines. This analysis found moderate cytotoxicities (2–50 μM) for the majority of the cell lines w...

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Vydáno v:Medchemcomm
Hlavní autoři: Aljahdali, Alhanouf Z., Freedman, Seth A., Scott, Jana, Li, Miaosheng, O'Doherty, George A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640558/
https://ncbi.nlm.nih.gov/pubmed/31391894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00121b
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