Increased tenofovir monoester concentrations in patients receiving tenofovir disoproxil fumarate with ledipasvir/sofosbuvir

BACKGROUND: Intracellular tenofovir diphosphate concentrations are markedly increased in HIV/HCV coinfected individuals receiving tenofovir disoproxil fumarate (TDF) with sofosbuvir-containing treatment. Sofosbuvir may inhibit the hydrolysis of TDF to tenofovir, resulting in increased concentrations...

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Библиографические подробности
Опубликовано в: :J Antimicrob Chemother
Главные авторы: Brooks, Kristina M, Castillo-Mancilla, Jose R, Blum, Joshua, Huntley, Ryan, MaWhinney, Samantha, Alexander, Keisha, Kerr, Becky Jo, Ellison, Lucas, Bushman, Lane R, MacBrayne, Christine E, Anderson, Peter L, Kiser, Jennifer J
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640288/
https://ncbi.nlm.nih.gov/pubmed/31081036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz184
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