Increased tenofovir monoester concentrations in patients receiving tenofovir disoproxil fumarate with ledipasvir/sofosbuvir

BACKGROUND: Intracellular tenofovir diphosphate concentrations are markedly increased in HIV/HCV coinfected individuals receiving tenofovir disoproxil fumarate (TDF) with sofosbuvir-containing treatment. Sofosbuvir may inhibit the hydrolysis of TDF to tenofovir, resulting in increased concentrations...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Brooks, Kristina M, Castillo-Mancilla, Jose R, Blum, Joshua, Huntley, Ryan, MaWhinney, Samantha, Alexander, Keisha, Kerr, Becky Jo, Ellison, Lucas, Bushman, Lane R, MacBrayne, Christine E, Anderson, Peter L, Kiser, Jennifer J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640288/
https://ncbi.nlm.nih.gov/pubmed/31081036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz184
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