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Prostaglandin E(2) Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite
We investigated the effects of prostaglandin E(2) (PGE(2)), an important inflammatory lipid mediator, on the cytotoxicity–genotoxicity induced by arsenite. With the use of a toxicity paradigm in which the metalloid uniquely induces mitochondrial superoxide (mitoO(2) (−.)) formation, PGE(2) promoted...
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| izdano v: | Front Pharmacol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6640088/ https://ncbi.nlm.nih.gov/pubmed/31354495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00781 |
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