Prostaglandin E(2) Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite

We investigated the effects of prostaglandin E(2) (PGE(2)), an important inflammatory lipid mediator, on the cytotoxicity–genotoxicity induced by arsenite. With the use of a toxicity paradigm in which the metalloid uniquely induces mitochondrial superoxide (mitoO(2) (−.)) formation, PGE(2) promoted...

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Publicado en:Front Pharmacol
Autores principales: Cerioni, Liana, Guidarelli, Andrea, Fiorani, Mara, Cantoni, Orazio
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640088/
https://ncbi.nlm.nih.gov/pubmed/31354495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00781
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