A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

HECT E3 ligases control the degradation and functioning of numerous oncogenic/tumor-suppressive factors and signaling proteins, and their activities must be tightly regulated to prevent cancers and other diseases. Here we show that the Nedd4 family HECT E3 WWP1 adopts an autoinhibited state, in whic...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Wang, Zhen, Liu, Ziheng, Chen, Xing, Li, Jingyu, Yao, Weiyi, Huang, Shijing, Gu, Aihong, Lei, Qun-Ying, Mao, Ying, Wen, Wenyu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639328/
https://ncbi.nlm.nih.gov/pubmed/31320636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11224-7
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker