CD8β Depletion Does Not Prevent Control of Viral Replication or Protection from Challenge in Macaques Chronically Infected with a Live Attenuated Simian Immunodeficiency Virus

We evaluated the contribution of CD8αβ(+) T cells to control of live-attenuated simian immunodeficiency virus (LASIV) replication during chronic infection and subsequent protection from pathogenic SIV challenge. Unlike previous reports with a CD8α-specific depleting monoclonal antibody (mAb), the CD...

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Udgivet i:J Virol
Main Authors: Sutton, Matthew S., Ellis-Connell, Amy, Balgeman, Alexis J., Barry, Gabrielle, Weiler, Andrea M., Hetzel, Scott J., Zhou, Yan, Lau-Kilby, Annie W., Mason, Rosemarie D., Biris, Kristin K., Mascola, John R., Sullivan, Nancy J., Roederer, Mario, Friedrich, Thomas C., O’Connor, Shelby L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639280/
https://ncbi.nlm.nih.gov/pubmed/31092584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00537-19
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