Vaccination with Live Attenuated Simian Immunodeficiency Virus (SIV) Protects from Mucosal, but Not Necessarily Intravenous, Challenge with a Minimally Heterologous SIV

Few studies have evaluated the impact of the viral challenge route on protection against a heterologous simian immunodeficiency virus (SIV) challenge. We vaccinated seven macaques with a live attenuated SIV that differed from SIVmac239Δnef by 24 amino acids, called m3KOΔnef. All animals were protect...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Sutton, Matthew S., Burns, Charles M., Weiler, Andrea M., Balgeman, Alexis J., Braasch, Andrew, Lehrer-Brey, Gabrielle, Friedrich, Thomas C., O'Connor, Shelby L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886799/
https://ncbi.nlm.nih.gov/pubmed/26962218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00192-16
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