FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair

Fanconi anemia (FA) is an inherited disease characterized by bone marrow failure and increased cancer risk. FA is caused by mutation of any 1 of 22 genes, and the FA proteins function cooperatively to repair DNA interstrand cross-links (ICLs). A central step in the activation of the FA pathway is th...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Paquin, Karissa L., Mamrak, Nicholas E., Garzon, Jada L., Cantres-Velez, Juan A., Azzinaro, Paul A., Vuono, Elizabeth A., Lima, Kevin E., Camberg, Jodi L., Howlett, Niall G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639249/
https://ncbi.nlm.nih.gov/pubmed/31085681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00194-19
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