Cyclin-Dependent Kinase-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity

Fanconi anemia (FA) is a rare genetic disease characterized by increased risk for bone marrow failure and cancer. The FA proteins function together to repair damaged DNA. A central step in the activation of the FA pathway is the monoubiquitination of the FANCD2 and FANCI proteins, which occurs upon...

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Udgivet i:Mol Cell Biol
Main Authors: Cantres-Velez, Juan A., Blaize, Justin L., Vierra, David A., Boisvert, Rebecca A., Garzon, Jada L., Piraino, Benjamin, Tan, Winnie, Deans, Andrew J., Howlett, Niall G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8300791/
https://ncbi.nlm.nih.gov/pubmed/34096775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00234-21
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