Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan

High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant cancer molecules in minimally invasive body fluid samples. We demonstrate 80% sensitivity for ovarian cancer detection using ultra-accurate Duplex Sequencing to i...

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Udgivet i:Cell Rep
Main Authors: Salk, Jesse J., Loubet-Senear, Kaitlyn, Maritschnegg, Elisabeth, Valentine, Charles C., Williams, Lindsey N., Higgins, Jacob E., Horvat, Reinhard, Vanderstichele, Adriaan, Nachmanson, Daniela, Baker, Kathryn T., Emond, Mary J., Loter, Emily, Tretiakova, Maria, Soussi, Thierry, Loeb, Lawrence A., Zeillinger, Robert, Speiser, Paul, Ana Risques, Rosa
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639023/
https://ncbi.nlm.nih.gov/pubmed/31269435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.109
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