Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan

Summary: High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant cancer molecules in minimally invasive body fluid samples. We demonstrate 80% sensitivity for ovarian cancer detection using ultra-accurate Duplex Sequen...

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Main Authors: Jesse J. Salk, Kaitlyn Loubet-Senear, Elisabeth Maritschnegg, Charles C. Valentine, Lindsey N. Williams, Jacob E. Higgins, Reinhard Horvat, Adriaan Vanderstichele, Daniela Nachmanson, Kathryn T. Baker, Mary J. Emond, Emily Loter, Maria Tretiakova, Thierry Soussi, Lawrence A. Loeb, Robert Zeillinger, Paul Speiser, Rosa Ana Risques
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019-07-01
Colecção:Cell Reports
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124719307569
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