Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas

Reports regarding the frequency of SMAD4 loss in human head and neck squamous cell carcinoma (HNSCC) vary significantly. We have shown that SMAD4 deletion contributes to HNSCC initiation and progression. Therefore, accurately detecting genetic SMAD4 loss is critical to determine prognosis and therap...

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Vydáno v:Mol Carcinog
Hlavní autoři: Hernandez, Ariel L., Wang, Ying, Somerset, Hilary L., Keysar, Stephen B., Aisner, Dara L., Marshall, Carrie, Bowles, Daniel W., Karam, Sana D., Raben, David, Jimeno, Antonio, Varella-Garcia, Marileila, Wang, Xiao-Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637962/
https://ncbi.nlm.nih.gov/pubmed/30575147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22958
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