Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas

Reports regarding the frequency of SMAD4 loss in human head and neck squamous cell carcinoma (HNSCC) vary significantly. We have shown that SMAD4 deletion contributes to HNSCC initiation and progression. Therefore, accurately detecting genetic SMAD4 loss is critical to determine prognosis and therap...

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Detalhes bibliográficos
Publicado no:Mol Carcinog
Main Authors: Hernandez, Ariel L., Wang, Ying, Somerset, Hilary L., Keysar, Stephen B., Aisner, Dara L., Marshall, Carrie, Bowles, Daniel W., Karam, Sana D., Raben, David, Jimeno, Antonio, Varella-Garcia, Marileila, Wang, Xiao-Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637962/
https://ncbi.nlm.nih.gov/pubmed/30575147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22958
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