Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production

Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity. However, insights into the role of CFH in B cell biology are limited. Here, we dem...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kiss, Máté G., Ozsvár-Kozma, Mária, Porsch, Florentina, Göderle, Laura, Papac-Miličević, Nikolina, Bartolini-Gritti, Barbara, Tsiantoulas, Dimitrios, Pickering, Matthew C., Binder, Christoph J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637296/
https://ncbi.nlm.nih.gov/pubmed/31354740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01607
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