IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer

Chronic obstructive pulmonary disease (COPD) is associated with neutrophilic lung inflammation and CD8 T cell exhaustion and is an important risk factor for the development of non-small cell lung cancer (NSCLC). The clinical response to programmed cell death-1 (PD-1) blockade in NSCLC patients is va...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ritzmann, Felix, Jungnickel, Christopher, Vella, Giovanna, Kamyschnikow, Andreas, Herr, Christian, Li, Dong, Menger, Michael M., Angenendt, Adrian, Hoth, Markus, Lis, Annette, Bals, Robert, Beisswenger, C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637115/
https://ncbi.nlm.nih.gov/pubmed/31316109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46759-8
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