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SPG7 targets the m-AAA protease complex to process MCU for uniporter assembly, Ca(2+) influx, and regulation of mitochondrial permeability transition pore opening

The mitochondrial matrix ATPase associated with diverse cellular activities (m-AAA) protease spastic paraplegia 7 (SPG7) has been recently implicated as either a negative or positive regulatory component of the mitochondrial permeability transition pore (mPTP) by two research groups. To address this...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Hurst, Stephen, Baggett, Ariele, Csordas, Gyorgy, Sheu, Shey-Shing
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635443/
https://ncbi.nlm.nih.gov/pubmed/31097542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006443
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