Myocardial-restricted ablation of the GTPase RAD results in a pro-adaptive heart response in mice

Existing therapies to improve heart function target β-adrenergic receptor (β-AR) signaling and Ca(2+) handling and often lead to adverse outcomes. This underscores an unmet need for positive inotropes that improve heart function without any adverse effects. The GTPase Ras associated with diabetes (R...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ahern, Brooke M., Levitan, Bryana M., Veeranki, Sudhakar, Shah, Mihir, Ali, Nemat, Sebastian, Andrea, Su, Wen, Gong, Ming C., Li, Jiayang, Stelzer, Julian E., Andres, Douglas A., Satin, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635439/
https://ncbi.nlm.nih.gov/pubmed/31147441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008782
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