Rad GTPase Deletion Attenuates Post-Ischemic Cardiac Dysfunction and Remodeling

The protein Rad interacts with the L-type calcium channel complex to modulate trigger Ca(2+) and hence to govern contractility. Reducing Rad levels increases cardiac output. Ablation of Rad also attenuated the inflammatory response following acute myocardial infarction. Future studies to target dele...

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Udgivet i:JACC Basic Transl Sci
Main Authors: Manning, Janet R., Chelvarajan, Lakshman, Levitan, Bryana M., Withers, Catherine N., Nagareddy, Prabhakara R., Haggerty, Christopher M., Fornwalt, Brandon K., Gao, Erhe, Tripathi, Himi, Abdel-Latif, Ahmed, Andres, Douglas A., Satin, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
PRECLINICAL RESEARCH
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931223/
https://ncbi.nlm.nih.gov/pubmed/29732439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2017.09.004
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