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Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging
Rad-GTPase is a regulator of L-type calcium current (LTCC), with increased calcium current observed in Rad knockout models. While mouse models that result in elevated LTCC have been associated with heart failure, our laboratory and others observe a hypercontractile phenotype with enhanced calcium ho...
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| Publicado no: | Am J Physiol Heart Circ Physiol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4631537/ https://ncbi.nlm.nih.gov/pubmed/26371164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00389.2015 |
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