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Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging

Rad-GTPase is a regulator of L-type calcium current (LTCC), with increased calcium current observed in Rad knockout models. While mouse models that result in elevated LTCC have been associated with heart failure, our laboratory and others observe a hypercontractile phenotype with enhanced calcium ho...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Heart Circ Physiol
Hoofdauteurs: Manning, Janet R., Withers, Catherine N., Levitan, Bryana, Smith, Jeffrey D., Andres, Douglas A., Satin, Jonathan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631537/
https://ncbi.nlm.nih.gov/pubmed/26371164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00389.2015
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