Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs

Mycobacterium tuberculosis (Mtb) SapM is a secreted virulence factor critical for intracellular survival of the pathogen. The role of SapM in phagosome maturation arrest in host macrophages suggests its potential as a drug target to assist in the clearance of tuberculosis infection. However, the mec...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Fernandez-Soto, Paulina, Bruce, Alexander J. E., Fielding, Alistair J., Cavet, Jennifer S., Tabernero, Lydia
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635428/
https://ncbi.nlm.nih.gov/pubmed/31312014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46731-6
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