The fbpA/sapM Double Knock Out Strain of Mycobacterium tuberculosis Is Highly Attenuated and Immunogenic in Macrophages

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death due to bacterial infections in mankind, and BCG, an attenuated strain of Mycobacterium bovis, is an approved vaccine. BCG sequesters in immature phagosomes of antigen presenting cells (APCs), which do not fu...

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Detalhes bibliográficos
Main Authors: Saikolappan, Sankaralingam, Estrella, Jaymie, Sasindran, Smitha J., Khan, Arshad, Armitige, Lisa Y., Jagannath, Chinnaswamy, Dhandayuthapani, Subramanian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344844/
https://ncbi.nlm.nih.gov/pubmed/22574140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036198
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