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The fbpA/sapM Double Knock Out Strain of Mycobacterium tuberculosis Is Highly Attenuated and Immunogenic in Macrophages

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death due to bacterial infections in mankind, and BCG, an attenuated strain of Mycobacterium bovis, is an approved vaccine. BCG sequesters in immature phagosomes of antigen presenting cells (APCs), which do not fu...

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Main Authors: Saikolappan, Sankaralingam, Estrella, Jaymie, Sasindran, Smitha J., Khan, Arshad, Armitige, Lisa Y., Jagannath, Chinnaswamy, Dhandayuthapani, Subramanian
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344844/
https://ncbi.nlm.nih.gov/pubmed/22574140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036198
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