The fbpA/sapM Double Knock Out Strain of Mycobacterium tuberculosis Is Highly Attenuated and Immunogenic in Macrophages

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death due to bacterial infections in mankind, and BCG, an attenuated strain of Mycobacterium bovis, is an approved vaccine. BCG sequesters in immature phagosomes of antigen presenting cells (APCs), which do not fu...

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Main Authors: Saikolappan, Sankaralingam, Estrella, Jaymie, Sasindran, Smitha J., Khan, Arshad, Armitige, Lisa Y., Jagannath, Chinnaswamy, Dhandayuthapani, Subramanian
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
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Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344844/
https://ncbi.nlm.nih.gov/pubmed/22574140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036198
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