Inhibition of FK506 Binding Proteins Reduces α-Synuclein Aggregation and Parkinson's Disease-Like Pathology

α-Synuclein (α-SYN) is a key player in the pathogenesis of Parkinson's disease (PD). In pathological conditions, the protein is present in a fibrillar, aggregated form inside cytoplasmic inclusions called Lewy bodies. Members of the FK506 binding protein (FKBP) family are peptidyl-prolyl isomer...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Gerard, Melanie, Deleersnijder, Angélique, Daniëls, Veronique, Schreurs, Sarah, Munck, Sebastian, Reumers, Veerle, Pottel, Hans, Engelborghs, Yves, Van den Haute, Chris, Taymans, Jean-Marc, Debyser, Zeger, Baekelandt, Veerle
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6634531/
https://ncbi.nlm.nih.gov/pubmed/20164329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5983-09.2010
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