Noninvasive Bioluminescence Imaging of α-Synuclein Oligomerization in Mouse Brain Using Split Firefly Luciferase Reporters

Alpha-synuclein (αSYN) aggregation plays a pivotal role in the pathogenesis of Parkinson's disease and other synucleinopathies. In this multistep process, oligomerization of αSYN monomers is the first step in the formation of fibrils and intracytoplasmic inclusions. Although αSYN oligomers are...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Aelvoet, Sarah-Ann, Ibrahimi, Abdelilah, Macchi, Francesca, Gijsbers, Rik, Van den Haute, Chris, Debyser, Zeger, Baekelandt, Veerle
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608487/
https://ncbi.nlm.nih.gov/pubmed/25471588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4933-13.2014
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