Comparative Analysis of Different Peptidyl-Prolyl Isomerases Reveals FK506-binding Protein 12 as the Most Potent Enhancer of α-Synuclein Aggregation

FK506-binding proteins (FKBPs) are members of the immunophilins, enzymes that assist protein folding with their peptidyl-prolyl isomerase (PPIase) activity. Some non-immunosuppressive inhibitors of these enzymes have neuroregenerative and neuroprotective properties with an unknown mechanism of actio...

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Main Authors: Deleersnijder, Angélique, Van Rompuy, Anne-Sophie, Desender, Linda, Pottel, Hans, Buée, Luc, Debyser, Zeger, Baekelandt, Veerle, Gerard, Melanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143632/
https://ncbi.nlm.nih.gov/pubmed/21652707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.182303
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