Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial

BACKGROUND: Rapid reversal of vitamin K antagonist (VKA)-induced anticoagulation is often necessary for patients needing urgent surgical or invasive procedures. The optimum means of VKA reversal has not been established in comparative clinical trials. We compared the efficacy and safety of four-fact...

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Gepubliceerd in:Lancet
Hoofdauteurs: Goldstein, Joshua N, Refaai, Majed A, Milling, Truman J, Lewis, Brandon, Goldberg-Alberts, Robert, Hug, Bruce A, Sarode, Ravi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633921/
https://ncbi.nlm.nih.gov/pubmed/25728933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(14)61685-8
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