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Safety of a Four‐factor Prothrombin Complex Concentrate Versus Plasma for Vitamin K Antagonist Reversal: An Integrated Analysis of Two Phase IIIb Clinical Trials

OBJECTIVES: Clinicians often need to rapidly reverse vitamin K antagonists (VKAs) in the setting of major hemorrhage or urgent need for surgery. Little is known about the safety profile of the traditional reversal agent, plasma, or the newly approved agent, four‐factor prothrombin complex concentrat...

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Publicat a:Acad Emerg Med
Autors principals: Milling, Truman J., Refaai, Majed A., Sarode, Ravi, Lewis, Brandon, Mangione, Antoinette, Durn, Billie L., Harman, Amy, Lee, Martin L., Goldstein, Joshua N.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071715/
https://ncbi.nlm.nih.gov/pubmed/26822172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acem.12911
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