Efficacy and Safety of a 4-Factor Prothrombin Complex Concentrate in Patients on Vitamin K Antagonists Presenting With Major Bleeding A Randomized, Plasma-Controlled, Phase IIIb Study

BACKGROUND—: Patients experiencing major bleeding while taking vitamin K antagonists require rapid vitamin K antagonist reversal. We performed a prospective clinical trial to compare nonactivated 4-factor prothrombin complex concentrate (4F-PCC) with plasma for urgent vitamin K antagonist reversal....

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Sarode, Ravi, Milling, Truman J., Refaai, Majed A., Mangione, Antoinette, Schneider, Astrid, Durn, Billie L., Goldstein, Joshua N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701181/
https://ncbi.nlm.nih.gov/pubmed/23935011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.002283
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