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Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence
The binding of DNA-dependent protein kinase catalytic subunit (DNA-PKcs, also known as PRKDC) to Ku proteins at DNA double-strand breaks (DSBs) has long been considered essential for non-homologous end joining (NHEJ) repair, providing a rationale for use of DNA-PKcs inhibitors as cancer therapeutics...
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| Publicado no: | J Cell Sci |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6633392/ https://ncbi.nlm.nih.gov/pubmed/31189537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.229385 |
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